Novel composite hydrogels of poly(acrylamide) (PAAm) and starch, at different ratios, were studied as potential platforms for controlled release of amoxicillin. The composite hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and swelling kinetic measurements. The morphology analysis revealed the presence of starch granules well embedded within the PAAm network. The increase in starch content increased the rate of water uptake and the swelling degree at equilibrium. The amoxicillin release kinetics was sensitive to pH and temperature conditions. The in vitro bacterial growth inhibition of antibiotic-loaded hydrogels was tested though disc diffusion assays with Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, and a carbapenemase producer Pseudomonas aeruginosa strain. The optimal release profile at physiological conditions and the powerful bacteria growth inhibition effects of amoxicillin-loaded hydrogels evidenced its potential for biomedical applications, particularly in oral administration and the local treatment of bacterial infections.

中文翻译：

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聚丙烯酰胺和淀粉复合水凝胶作为阿莫西林控释和抑制细菌生长的潜在系统

研究了不同比例的聚（丙烯酰胺）（PAAm）和淀粉的新型复合水凝胶作为阿莫西林控释的潜在平台。通过傅里叶变换红外光谱 (FTIR)、扫描电子显微镜 (SEM)、能量色散 X 射线光谱 (EDX) 和溶胀动力学测量对复合水凝胶进行了表征。形态分析表明存在很好地嵌入 PAAm 网络中的淀粉颗粒。淀粉含量的增加增加了吸水率和平衡时的溶胀度。阿莫西林的释放动力学对 pH 值和温度条件敏感。通过使用大肠杆菌 ATCC 25922、金黄色葡萄球菌 ATCC 25923、和碳青霉烯酶生产者铜绿假单胞菌菌株。生理条件下的最佳释放曲线和阿莫西林负载水凝胶强大的细菌生长抑制作用证明了其在生物医学应用中的潜力，特别是在口服给药和细菌感染的局部治疗中。