当前位置: X-MOL 学术Phys. Rev. E › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Vertex model instabilities for tissues subject to cellular activity or applied stresses
Physical Review E ( IF 2.4 ) Pub Date : 2020-11-16 , DOI: 10.1103/physreve.102.052604
Fernanda Pérez-Verdugo 1 , Jean-Francois Joanny 2, 3 , Rodrigo Soto 1
Affiliation  

The vertex model is widely used to describe the dynamics of epithelial tissues, because of its simplicity and versatility and the direct inclusion of biophysical parameters. Here, it is shown that quite generally, when cells modify their equilibrium perimeter due to their activity, or the tissue is subject to external stresses, the tissue becomes unstable with deformations that couple pure shear or deviatoric modes, with rotation and expansion modes. For short times, these instabilities deform cells, increasing their ellipticity, while at longer times cells become nonconvex, indicating that the vertex model ceases to be a valid description for tissues under these conditions. The agreement between the analytic calculations performed for a regular hexagonal tissue and the simulations of disordered tissues is excellent due to the homogenization of the tissue at long wavelengths.

中文翻译:

受细胞活动或施加压力影响的组织的顶点模型不稳定性

顶点模型因其简单性和多功能性以及直接包含生物物理参数而被广泛用于描述上皮组织的动力学。在这里,很普遍地表明,当细胞由于其活动而改变其平衡周长时,或者组织受到外部应力时,组织变得不稳定,变形会耦合纯剪切或偏斜模式,以及旋转和扩张模式。在短时间内,这些不稳定性使细胞变形,增加了它们的椭圆度,而在更长的时间内,细胞变得非凸面,表明在这些条件下,顶点模型不再是对组织的有效描述。
更新日期:2020-11-16
down
wechat
bug