Acupuncturing the ST36 acupoint can evoke the response of the sensory nervous system, which is translated into output electrical signals in the spinal dorsal root. Neural response activities, especially synchronous spike events, evoked by different acupuncture manipulations have remarkable differences. In order to identify these network collaborative activities, we analyze the underlying spike correlation in the synchronous spike event. In this paper, we adopt a log-linear model to describe network response activities evoked by different acupuncture manipulations. Then the state-space model and Bayesian theory are used to estimate network spike correlations. Two sets of simulation data are used to test the effectiveness of the estimation algorithm and the model goodness-of-fit. In addition, simulation data are also used to analyze the relationship between spike correlations and synchronous spike events. Finally, we use this method to identify network spike correlations evoked by four different acupuncture manipulations. Results show that reinforcing manipulations (twirling reinforcing and lifting-thrusting reinforcing) can evoke the third-order spike correlation but reducing manipulations (twirling reducing and lifting-thrusting reducing) does not. This is the main reason why synchronous spikes evoked by reinforcing manipulations are more abundant than reducing manipulations.

中文翻译：

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针刺机械刺激诱发的同步尖峰脉冲相关分析

针刺ST36穴位可以唤起感觉神经系统的反应，在脊髓背根转化为输出电信号。不同针刺手法诱发的神经反应活动，尤其是同步尖峰事件存在显着差异。为了识别这些网络协作活动，我们分析了同步尖峰事件中潜在的尖峰相关性。在本文中，我们采用对数线性模型来描述不同针灸操作引起的网络反应活动。然后使用状态空间模型和贝叶斯理论来估计网络尖峰相关性。两组仿真数据用于检验估计算法的有效性和模型的拟合优度。此外，模拟数据还用于分析尖峰相关性和同步尖峰事件之间的关系。最后，我们使用这种方法来识别由四种不同的针灸操作引起的网络尖峰相关性。结果表明，强化操作（旋转强化和提升-推进强化）可以唤起三阶尖峰相关性，但减少操作（旋转减少和提升-推进减少）不会。这是强化操作引起的同步尖峰比减少操作更丰富的主要原因。结果表明，强化操作（旋转强化和提升-推进强化）可以唤起三阶尖峰相关性，但减少操作（旋转减少和提升-推进减少）不会。这是强化操作引起的同步尖峰比减少操作更丰富的主要原因。结果表明，强化操作（旋转强化和提升-推进强化）可以唤起三阶尖峰相关性，但减少操作（旋转减少和提升-推进减少）不会。这是强化操作引起的同步尖峰比减少操作更丰富的主要原因。