当前位置: X-MOL 学术J. Cell Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Periodic subcellular structures undergo long-range synchronized reorganization during C. elegans epidermal development
Journal of Cell Science ( IF 4 ) Pub Date : 2020-11-03 , DOI: 10.1242/jcs.246793
Chunxia Wang 1 , Yuyan Yang 1 , Rong Fu 1 , Yi Zhu 1 , Huimin Zhang 2
Affiliation  

Chunxia Wang, Yuyan Yang, Rong Fu, Yi Zhu, and Huimin Zhang

Periodic pattern formation on the cellular and tissue scale is an important process and has been extensively studied. However, periodic pattern formation at the subcellular level still remains poorly understood. The C. elegans epidermis displays a highly ordered parallel stripe pattern as part of its subcellular structure, making it an ideal model to study the formation and reorganization of periodic patterns within cells. Here, we show that the initial formation of periodic striped patterns in the C. elegans epidermis is dependent on actin and spectrin, and requires the apical membrane attachment structures for maintenance. The periodic subcellular structures do not accommodate cell growth by continuously making new stripes. Instead, they increase the number of stripes by going through one round of uniform duplication, which is independent of the increasing epidermal length or the developmental cycles. This long-range synchronized reorganization of subcellular structures is achieved by physical links established by extracellular collagens together with extension forces generated from epidermal cell growth. Our studies uncover a novel strategy employed by evenly spaced and interlinked subcellular structures to maintain their integrity and equidistribution during cell growth and tissue development.



中文翻译:

周期性亚细胞结构在秀丽隐杆线虫表皮发育过程中经历长程同步重组

王春霞、杨玉艳、付蓉、朱毅、张慧敏

细胞和组织尺度上的周期性图案形成是一个重要的过程,并且已被广泛研究。然而,人们对亚细胞水平的周期性模式形成仍然知之甚少。秀丽隐杆线虫表皮显示出高度有序的平行条纹图案作为其亚细胞结构的一部分,使其成为研究细胞内周期性图案的形成和重组的理想模型。在这里,我们表明,秀丽隐杆线虫表皮中周期性条纹图案的最初形成依赖于肌动蛋白和血影蛋白,并且需要顶膜附着结构来维持。周期性的亚细胞结构不能通过不断产生新的条纹来适应细胞的生长。相反,它们通过一轮均匀复制来增加条纹数量,这与表皮长度的增加或发育周期无关。这种亚细胞结构的远程同步重组是通过细胞外胶原蛋白建立的物理连接以及表皮细胞生长产生的伸展力来实现的。我们的研究揭示了均匀间隔和互连的亚细胞结构采用的一种新策略,以在细胞生长和组织发育过程中保持其完整性和均匀分布。

更新日期:2020-11-16
down
wechat
bug