Abstract

Aim

The purpose of this study is to observe the volume change of prostate and laser-ablated lesions in the canine and to explore the mechanism and clinical significance through histopathology.

Materials and methods

Transperineal laser ablation (TPLA) was performed under the guidance of transrectal ultrasound (TRUS) in eight canines. Two canines were sacrificed 1 day and 1 week after TPLA, respectively. The remaining six canines were sacrificed after finishing transrectal contrast-enhanced ultrasound (TR-CEUS) at three phases.

Results

The prostatic volumes immediately following TPLA and 1 week later were larger than before TPLA (20.1 ± 3.9 vs 17.1 ± 3.8 ml; 21.7 ± 3.6 vs 17.1 ± 3.8 ml, p < 0.05), but 1 month later, returned to the preoperative level (17.4 ± 3.2 ml). At three time points, the mean volumes of laser-ablated lesions at 3 W/600 J were 0.6 ± 0.2, 1.1 ± 0.4, and 1.7 ± 0.5 ml, respectively, while those of laser-ablated lesions at 3 W/1200 J were 1.2 ± 0.2, 1.6 ± 0.3, and 2.2 ± 0.5 ml, respectively. The mean volumes of laser-ablated lesions increased significantly over time after TPLA (p < 0.050).

Conclusion

The prostate volume transient enlarges after TPLA, which prompts for clinical application that it should prolong appropriately the duration of urinary catheterization to avoid acute urinary retention. Many inflammatory cells were observed in the laser-ablated lesions and adjacent normal prostate parenchyma through histopathology. It is speculated that the inflammatory response is involved in the progression of tissue damage.

中文翻译：

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经会阴激光消融后犬动态前列腺和激光消融病变体积变化的初步观察及其临床意义

摘要

目标

这项研究的目的是观察犬的前列腺和激光消融灶的体积变化，并通过组织病理学探讨其机制和临床意义。

材料和方法

在八只犬的经直肠超声（TRUS）的指导下进行会阴激光消融（TPLA）。TPLA后1天和1周分别处死两个犬。在三个阶段完成经直肠对比增强超声（TR-CEUS）后，将剩下的六个犬杀死。

结果

TPLA之后和1周后立即的前列腺体积大于TPLA前（20.1±3.9 vs 17.1±3.8 ml; 21.7±3.6 vs 17.1±3.8 ml，p  <0.05），但1个月后恢复到术前水平（ 17.4±3.2毫升）。在三个时间点，3 W / 600 J的激光消融灶的平均体积分别为0.6±0.2、1.1±0.4和1.7±0.5 ml，而3 W / 1200 J的激光消融灶的平均体积分别为分别为1.2±0.2、1.6±0.3和2.2±0.5 ml。TPLA后，激光消融灶的平均体积随时间显着增加（p  <0.050）。

结论

TPLA后前列腺体积瞬变增大，这提示临床应用应适当延长导尿的持续时间，以避免急性尿retention留。通过组织病理学在激光切除的病变和邻近的正常前列腺实质中观察到许多炎性细胞。据推测，炎症反应与组织损伤的进展有关。