Abstract

Objective

Cortical priming is an emerging strategy to enhance motor recovery after stroke, however, limited information exists on the neuromodulatory effects of lower limb movement-based priming to facilitate corticomotor excitability after stroke. In this study, we investigated the feasibility and effectiveness of game-based ankle movement priming using the DIG-I-PRIME™ on corticomotor excitability and motor performance in chronic stroke survivors.

Methods

Nineteen stroke survivors participated in a 20-min session of game-based priming. A period of rest served as a control for the priming condition. Transcranial magnetic stimulation (TMS) was used to measure corticomotor excitability of the paretic and non-paretic tibialis anterior (TA) muscle representations. Motor performance was quantified by assessing the accuracy to track a sinusoidal target wave with paretic dorsiflexion and plantarflexion.

Results

Ipsilesional corticomotor excitability increased by 25% after game-based movement priming (p = 0.02) while changes were not observed after the control condition. No change in motor performance was noted.

Conclusion

Game-based ankle movement priming demonstrated a significant acute priming effect on the ipsilesional lower limb M1. These data provide preliminary evidence for the potential benefits of game-based priming to promote functional recovery after stroke.

中文翻译：

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基于游戏的运动促进中风的急性启动效应

摘要

客观的

皮质启动是增强中风后运动恢复的新兴策略，但是，关于基于下肢运动的启动促进中风后皮质运动兴奋的神经调节作用的信息有限。在这项研究中，我们使用 DIG-I-PRIME™ 调查了基于游戏的踝关节运动启动对慢性中风幸存者的皮质运动兴奋性和运动表现的可行性和有效性。

方法

19 名中风幸存者参加了 20 分钟的基于游戏的启动会议。休息一段时间作为启动条件的对照。经颅磁刺激 (TMS) 用于测量麻痹和非麻痹胫骨前 (TA) 肌肉表现的皮质运动兴奋性。通过评估跟踪具有麻痹性背屈和跖屈的正弦目标波的准确性来量化运动性能。

结果

在基于游戏的运动启动 ( p  = 0.02)后，同侧皮质运动兴奋性增加了 25%，而在控制条件后未观察到变化。没有注意到运动性能的变化。

结论

基于游戏的踝关节运动启动对同侧下肢 M1 显示出显着的急性启动效应。这些数据为基于游戏的启动促进卒中后功能恢复的潜在益处提供了初步证据。