Abstract

Purpose

It is known that obesity can be a risk factor for many types of cancer, including the pancreas. Visceral obesity rather than overall obesity is held more responsible for this relationship. This study aimed to evaluate the relationship of adipose tissue areas and their distribution (subcutaneous and visceral) with pancreatic ductal adenocarcinoma (PDAC) in male patients.

Materials and-Method

The medical data and abdominopelvic computed tomography (CT) examinations of male patients diagnosed with PDAC who underwent surgery or a biopsy in our hospital between January 2015 and January 2020 were retrospectively evaluated. An age-matched control group was formed from 49 male patients who underwent CT with a preliminary diagnosis of urinary stone without a history of malignancy and weight loss and no malignancy on CT at the time of presentation. Adipose tissue areas (total [TAT], visceral [VAT] and subcutaneous [SAT]) were measured in both groups, their VAT/TAT, VAT/SAT and SAT/TAT ratios were calculated, and the data were compared between the two groups.

Results

Patients with PDAC had significantly greater TAT, VAT and SAT areas than the control group (p = 0.002, p = 0.01, and p = 0.003, respectively). However, there was no significant differences in the VAT/TAT, VAT/SAT and SAT/TAT ratios between the two groups (p = 0.60, p = 0.60, and p = 0.73, respectively).

Conclusion

In this study, all adipose tissue areas (VAT, SAT, and TAT) were shown to be increased in male patients with PDAC. Both visceral obesity and overall obesity present as risk factors for PDAC in male patients.

中文翻译：

---

CT检查腹部脂肪组织面积与男性胰腺导管腺癌的关系

摘要

目的

众所周知，肥胖可能是多种癌症的危险因素，包括胰腺癌。内脏肥胖而不是整体肥胖对这种关系负有更大的责任。本研究旨在评估男性患者脂肪组织区域及其分布（皮下和内脏）与胰腺导管腺癌（PDAC）的关系。

材料和方法

回顾性评价2015年1月至2020年1月在我院接受手术或活检的确诊为PDAC的男性患者的医学资料和腹盆腔CT检查。年龄匹配的对照组由 49 名接受 CT 初步诊断为泌尿系结石且无恶性病史和体重减轻且在就诊时 CT 上未发现恶性肿瘤的男性患者组成。测量两组脂肪组织面积（总[TAT]、内脏[VAT]和皮下[SAT]），计算其VAT/TAT、VAT/SAT和SAT/TAT比值，并比较两组数据.

结果

PDAC 患者的 TAT、VAT 和 SAT 面积显着大于对照组（分别为p  = 0.002、p  = 0.01 和p  = 0.003）。然而，两组的 VAT/TAT、VAT/SAT 和 SAT/TAT 比率没有显着差异（分别为p  = 0.60、p  = 0.60 和p  = 0.73）。

结论

在这项研究中，PDAC 男性患者的所有脂肪组织区域（增值税、SAT 和 TAT）均显示增加。内脏肥胖和整体肥胖都是男性患者 PDAC 的危险因素。