Measurable residual disease (MRD) is a strong independent poor prognostic factor for acute leukemia. Multiparameter flow cytometry (FCM) is a commonly used MRD detection method. However, FCM MRD detection is not well standardized, and the interpretation is subjective. There are normal/reactive minor cell populations in bone marrow (BM) and peripheral blood (PB), which could be confused with MRD.

中文翻译：

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骨髓和外周血中的正常或反应性小细胞群通过流式细胞术模拟最小残留白血病

可测量残留病灶（MRD）是急性白血病的一个强有力的独立不良预后因素。多参数流式细胞仪（FCM）是一种常用的MRD检测方法。但是，FCM MRD 检测没有很好的标准化，并且解释是主观的。骨髓 (BM) 和外周血 (PB) 中存在正常/反应性小细胞群，可能与 MRD 混淆。