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Current Trends in In Vitro Modeling to Mimic Cellular Crosstalk in Periodontal Tissue
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-16 , DOI: 10.1002/adhm.202001269
Sanja Aveic 1, 2 , Rogerio B. Craveiro 3 , Michael Wolf 3 , Horst Fischer 1
Affiliation  

Clinical evidence indicates that in physiological and therapeutic conditions a continuous remodeling of the tooth root cementum and the periodontal apparatus is required to maintain tissue strength, to prevent damage, and to secure teeth anchorage. Within the tooth's surrounding tissues, tooth root cementum and the periodontal ligament are the key regulators of a functional tissue homeostasis. While the root cementum anchors the periodontal fibers to the tooth root, the periodontal ligament itself is the key regulator of tissue resorption, the remodeling process, and mechanical signal transduction. Thus, a balanced crosstalk of both tissues is mandatory for maintaining the homeostasis of this complex system. However, the mechanobiological mechanisms that shape the remodeling process and the interaction between the tissues are largely unknown. In recent years, numerous 2D and 3D in vitro models have sought to mimic the physiological and pathophysiological conditions of periodontal tissue. They have been proposed to unravel the underlying nature of the cell–cell and the cell–extracellular matrix interactions. The present review provides an overview of recent in vitro models and relevant biomaterials used to enhance the understanding of periodontal crosstalk and aims to provide a scientific basis for advanced regenerative strategies.

中文翻译:

在牙周组织中模拟细胞串扰的体外建模的当前趋势。

临床证据表明,在生理和治疗条件下,需要对牙根牙骨质和牙周装置进行连续重塑,以保持组织强度,防止损伤和固定牙齿。在牙齿周围的组织中,牙根牙骨质和牙周膜是功能组织动态平衡的关键调节器。虽然牙骨质将牙周纤维锚固到牙根,但牙周膜本身是组织吸收,重塑过程和机械信号转导的关键调节器。因此,两个组织的平衡串扰对于维持该复杂系统的稳态是必不可少的。但是,塑造重塑过程和组织之间相互作用的力学生物学机制在很大程度上尚不清楚。近年来,许多2D和3D体外模型都试图模仿牙周组织的生理和病理生理状况。已经提出了它们来揭示细胞间以及细胞与细胞外基质相互作用的潜在本质。本综述概述了最近的体外模型和用于增强对牙周串扰的理解的相关生物材料,旨在为先进的再生策略提供科学依据。
更新日期:2021-01-06
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