Fluorescence‐based hydrogel glucose sensors with boronic acid‐based glucose recognition are promising regarding their potential to improve continuous glucose monitoring by facilitating long‐lasting accuracy. However, these sensors typically become encapsulated after implantation, and the dynamic range decreases following long‐term implantation and use. Herein, a four‐arm polyethylene glycol (PEG) hydrogel is developed with an immobilized glucose‐responsive fluorescence dye (GF‐PEG‐gel); this hydrogel is effective in mitigating foreign body reactions (FBRs) that hinder stable glucose responses in vivo. The GF‐PEG‐gel attached to an implantable device successfully traces blood glucose concentrations in diabetic model rats for 45 days. A pig experiment shows that the device measures the glucose concentration with an equivalent accuracy to that required for clinically available settings.

中文翻译：

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使用基于荧光的生物相容性水凝胶葡萄糖传感器进行长期连续葡萄糖监测

具有基于硼酸的葡萄糖识别功能的基于荧光的水凝胶葡萄糖传感器具有潜力，可通过促进持久的准确性来改善连续的葡萄糖监测。但是，这些传感器通常在植入后被封装，并且在长期植入和使用后，动态范围会减小。本文中，开发了一种四臂聚乙二醇（PEG）水凝胶，其上固定了葡萄糖反应性荧光染料（GF-PEG-gel）。这种水凝胶可有效缓解异物反应（FBR），而异物反应会阻碍体内稳定的葡萄糖反应。连接至可植入装置的GF-PEG-凝胶成功追踪了糖尿病模型大鼠的血糖浓度达45天。