The purinergic receptor ligand, ATP, may participate in reflex induced vasoconstriction through sympathetic efferent and sensory afferent mechanisms. However, the role of the purinergic system in contributing to autonomic dysreflexia following spinal cord injury is unclear. The present study investigates the involvement of P2X receptors in contributing to pressor responses during autonomic dysreflexia. Twenty rats were subjected to spinal cord injury and 24 h later hemodynamic responses to colorectal distension were recorded. Animals were randomized to receive intravenous administration of the P2X receptor antagonist, NF023, or vehicle control. The data indicate that NF023 attenuates pressor responses to colorectal distension.

中文翻译：

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嘌呤能受体拮抗作用：一种可行的自主神经反射异常管理策略？

嘌呤能受体配体 ATP 可能通过交感神经传出和感觉传入机制参与反射诱导的血管收缩。然而，嘌呤能系统在脊髓损伤后导致自主神经反射异常中的作用尚不清楚。本研究调查了 P2X 受体在自主神经反射异常期间参与升压反应的情况。对 20 只大鼠进行脊髓损伤，并记录 24 小时后对结直肠扩张的血流动力学反应。动物随机接受 P2X 受体拮抗剂、NF023 或载体对照的静脉内给药。数据表明 NF023 减弱了对结直肠扩张的升压反应。