Bisphenols are endocrine-disrupting chemicals found in a broad range of products that can modulate hormonal signalling pathways and various other biological functions. These compounds can bind steroid receptors, e.g. estrogen and androgen receptors, expressed by numerous cells and tissues, including the prostate and the bladder, with the potential to alter their homeostasis and normal physiological functions. In the past years, exposure to bisphenols was linked to cancer progression and metastasis. As such, recent pieces of evidence suggest that endocrine-disrupting chemicals can lead to the development of prostate cancer. Moreover, bisphenols are found in the urine of the wide majority of the population. They could potentially affect the bladder's normal physiology and cancer development, even if the bladder is not recognized as a hormone-sensitive tissue. This review will focus on prostate and bladder malignancies, two urological cancers that share standard carcinogenic processes. The description of the underlying mechanisms involved in cell toxicity, and the possible roles of bisphenols in the development of prostate and bladder cancer, could help establish the putative roles of bisphenols on public health.

双酚是破坏内分泌的化学物质，存在于多种产品中，可以调节激素信号通路和各种其他生物学功能。这些化合物可以结合包括前列腺和膀胱在内的许多细胞和组织表达的类固醇受体，例如雌激素和雄激素受体，具有改变其体内稳态和正常生理功能的潜力。在过去的几年中，双酚的暴露与癌症的进展和转移有关。因此，最近的证据表明破坏内分泌的化学物质可导致前列腺癌的发展。此外，在大多数人的尿液中都发现了双酚。它们可能会影响膀胱的正常生理和癌症发展，即使膀胱未被识别为激素敏感性组织。这篇综述将聚焦于前列腺癌和膀胱恶性肿瘤，这是两种具有标准致癌过程的泌尿外科癌症。对涉及细胞毒性的潜在机制的描述以及双酚在前列腺癌和膀胱癌发展中的可能作用可能有助于确立双酚在公共卫生方面的假定作用。