Neonicotinoids are the most widely used synthetic insecticides in the world. These insecticides are widely distributed in the ecosystem, indicating that more attention should be paid to the potential risks regarding their use in agriculture. Due their intensive use, non-target species in the environment are also exposed to their putative effects. Within acute exposure trials, the time related effect of sublethal dose of the neonicotinoid preparation APACS 50 WG was investigated on swimming behaviour and the multi-xenobiotic resistance system (MXR) activity, as a first line defence pathway of adult Dikerogammarus villosus. Results showed that treated animals manifested an increased swimming activity. Exposed animals were monitored by the rhodamine B accumulation assay, and APACS 50 WG exerted distinct changes in the MXR activity as well. Our results suggested that application of neonicotinoid at a low concentration (3.9 ng/l) contributed to the activation of locomotor activity and at the same concentration range the transmembrane transport mechanisms was altered too.

新烟碱类是世界上使用最广泛的合成杀虫剂。这些杀虫剂在生态系统中分布广泛，表明其在农业中使用的潜在风险应引起更多关注。由于它们的大量使用，环境中的非目标物种也受到其推定的影响。在急性暴露试验中，研究了新烟碱类制剂 APACS 50 WG 的亚致死剂量对游泳行为和多异生物质抗性系统 (MXR) 活性的时间相关影响，作为成年绒毛双歧杆菌的第一道防线途径. 结果显示接受治疗的动物表现出增加的游泳活动。暴露的动物通过罗丹明 B 积累测定进行监测，APACS 50 WG 也对 MXR 活性产生了明显的变化。我们的结果表明，应用低浓度 (3.9 ng/l) 的新烟碱有助于激活运动活性，并且在相同的浓度范围内，跨膜转运机制也发生了改变。