Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope is presented and evaluated. The identified morphological features–cell groups with reticulin framework–detectable with UHR-OCT showcase a promising differentiation ability, encouraging endoscopic OCT probe development for in vivo application.

中文翻译：

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基于超高分辨率 OCT 的内窥镜垂体和腺瘤筛查：​​性能参数评估

首次研究了用于区分垂体组织和腺瘤组织的超高分辨率光学相干断层扫描 (UHR-OCT)，其准确率超过 80%。对于生物标志物识别，石蜡包埋组织的 OCT 图像与组织病理学切片相关。所识别的生物标志物在新鲜活检中得到验证。此外，还提出并评估了一种基于分辨率修改的 UHR-OCT离体数据的方法，研究用于体内内窥镜实现的光学性能参数。所鉴定的形态特征（具有网状蛋白框架的细胞群）可通过 UHR-OCT 检测，展示出有前景的分化能力，鼓励内窥镜 OCT 探针的体内应用开发。