Owing to the tremendous advantages and unique well‐defined nanoscale structure, polyhedral oligomeric silsesquioxanes (POSS) have received considerable interest in the design of novel organic‐inorganic hybrid nanomaterials with all manner of prominent capabilities, which is recognized as a new generation of promising materials for advanced applications of material science, engineering science and biomedical fields. Benefitting from the recent progress in combination of controlled/living polymerization and emerging click chemistry, POSS‐based hybrid materials with ingenious design, versatile topological structure and sophisticated multifunctionality have been successfully fabricated and developed into abundant well‐defined hybrid nanostructures with desired physicochemical properties. Tailor‐made amphiphilic molecular design and nanosized hybrid architecture provide opportunities for the self‐assembly of POSS‐based hybrid materials with unique hierarchical morphologies in selective solvents. Through the in‐depth understanding of structure‐properties relationship, POSS‐based hybrid materials can achieve the modulation of precise control of self‐assembling process and multi‐purpose applications with improved material performances. In this review, we summarize the recent advances of POSS‐based hybrid materials in molecular design, self‐assembly behavior in solutions and potential biomedical applications with main concerns on drug delivery, gene therapy, bioimaging and tissue engineering field. Finally, future directions and remaining challenges for further advancement of POSS‐based hybrid materials are proposed and discussed.

中文翻译：

---

基于多面体低聚倍半硅氧烷（POSS）的杂化材料：分子设计，溶液自组装和生物医学应用

由于其巨大的优势和独特的定义明确的纳米级结构，多面体低聚倍半硅氧烷（POSS）在设计具有各种显着功能的新型有机-无机杂化纳米材料方面引起了极大的兴趣，被认为是新一代有前途的材料适用于材料科学，工程科学和生物医学领域的高级应用。得益于受控/活性聚合和新兴的点击化学相结合的最新进展，具有成功的设计，新颖的设计，通用的拓扑结构和复杂的多功能性的基于POSS的杂化材料已被成功制造，并发展成为具有理想理化性质的丰富的定义明确的杂化纳米结构。量身定制的两亲分子设计和纳米级混合体系结构为基于POSS的混合材料的自组装提供了机会，该材料在选择性溶剂中具有独特的分层形态。通过对结构-特性关系的深入了解，基于POSS的混合材料可以实现对自组装过程和多用途应用的精确控制的调制，从而改善材料性能。在这篇综述中，我们总结了基于POSS的混合材料在分子设计，溶液中的自组装行为以及潜在的生物医学应用方面的最新进展，主要关注药物输送，基因治疗，生物成像和组织工程领域。最后，提出并讨论了进一步发展基于POSS的混合材料的未来方向和尚存的挑战。