A novel pH‐activatable fluorescent probe, 1‐(propan‐2‐yl)‐9H‐pyrido[3,4‐b]indole‐3‐carboxylic acid (L‐1), based on β‐carboline derivatives, has been developed, which displays significant fluorescent response toward pH variation with high selectivity, good photo‐stability and favorable pKa value. Moreover, L‐1 can dynamically monitor the release of protons during ester hydrolysis reaction in consistent with enzymatic kinetics manner.

中文翻译：

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基于β-咔啉的pH荧光探针及其在酶促酯水解监测中的应用

基于β-咔啉衍生物的新型pH可激活荧光探针1-(丙-2-基)-9H-吡啶并[3,4-b]吲哚-3-羧酸(L-1)已被开发，它对 pH 变化显示出显着的荧光响应，具有高选择性、良好的光稳定性和有利的 pKa 值。此外，L-1 可以与酶动力学方式一致地动态监测酯水解反应过程中质子的释放。