The treatment effect of ethanamizuril (EZL) to broiler chickens experimentally infected with 8 × 10⁴ Eimeria tenella was evaluated. On the third day after infection, the broiler chickens were treated with EZL by gavage at doses of 2, 4, and 8 mg/kg body weight (bw) for once. For double administration, the challenged broiler chickens were administered EZL at doses of 1, 2, 4, and 8 mg/kg bw by gavage continually on the third day and fourth day and once a day. Throughout the experimental period, performance parameters including body weight gain, mortality, cecal lesion score, bloody diarrhoea and oocyst output were recorded. The anticoccidial efficacy was evaluated using the anticoccidial index (ACI). Meanwhile, the concentrations of EZL in chicken cecal contents were measured, and the data were analyzed with a non-compartmental model. The results indicated that EZL showed good anticoccidial activity at single dose of 4 mg/kgbw, with the corresponding ACI of 175.73. When the challenged chickens were treated with EZL under double administration, the EZL showed a medium level of anticoccidial activity at a dose of 2 mg/kg bw, with the corresponding ACI of 162.48. The maximum concentrations (C_max) of EZL in content were 2.43 ± 1.16, 4.28 ± 1.56, and 8.57 ± 1.33 mg/kg after the chickens were administrated at doses of 2, 4, and 8 mg/kg bw, respectively. The respective areas under the curve were 36.93 ± 8.91, 96 ± 16.31, and 262.76 ± 51.52 mg/kg h. The respective half-lives (T_1/2) were 10.82 ± 2.02, 10.53 ± 2.23, and 10.60 ± 1.50 h. The results show that when the concentrations of EZL in chicken cecal contents reached 4.28 ± 1.56 mg/kg, there is a significant therapeutic effect on chicken coccidiosis.

评价乙胺珠利(EZL)对实验感染8×10 ⁴ 柔嫩艾美耳球虫的肉鸡的治疗效果。感染后第3天，肉鸡按2、4、8 mg/kg体重(bw)灌胃EZL各1次。对于双重施用，攻击的肉鸡在第三天和第四天连续灌胃施用EZL，剂量为1、2、4和8mg/kg体重，每天一次。在整个实验期间，记录了包括体重增加、死亡率、盲肠病变评分、血性腹泻和卵囊排出量在内的性能参数。使用抗球虫指数（ACI）评估抗球虫功效。同时测定鸡盲肠内容物中EZL的浓度，并用非房室模型对数据进行分析。结果表明，EZL在单剂量4 mg/kgbw时表现出良好的抗球虫活性，相应的ACI为175.73。当EZL双重给药时，EZL在2mg/kg体重的剂量下表现出中等水平的抗球虫活性，相应的ACI为162.48。鸡按2、4、8mg/kg体重给药后，EZL含量的最大浓度(C max )分别为2.43±1.16、4.28±1.56、8.57±1.33mg/ kg _。曲线下面积分别为36.93±8.91、96±16.31和262.76±51.52mg/kg·h。各自的半衰期(T _1/2 )为10.82±2.02、10.53±2.23和10.60±1.50小时。结果表明，当鸡盲肠内容物中EZL浓度达到4.28±1.56 mg/kg时，对鸡球虫病有显着的治疗作用。