Pancreatic cancer is one of the most common causes of cancer death in the world due to the lack of early symptoms, metastasis occurrence and chemoresistance. Therefore, early diagnosis by detection of biomarkers, blockade of metastasis, and overcoming chemoresistance are the effective strategies to improve the survival of pancreatic cancer patients. Accumulating evidence has revealed that long noncoding RNA (lncRNA) and circular RNAs (circRNAs) play essential roles in modulating chemosensitivity in pancreatic cancer. In this review article, we will summarize the role of lncRNAs in drug resistance of pancreatic cancer cells, including HOTTIP, HOTAIR, PVT1, linc-ROR, GAS5, UCA1, DYNC2H1-4, MEG3, TUG1, HOST2, HCP5, SLC7A11-AS1 and CASC2. We also highlight the function of circRNAs, such as circHIPK3 and circ_0000284, in regulation of drug sensitivity of pancreatic cancer cells. Moreover, we describe a number of compounds, including curcumin, genistein, resveratrol, quercetin, and salinomycin, which may modulate the expression of lncRNAs and enhance chemosensitivity in pancreatic cancers. Therefore, targeting specific lncRNAs and cicrRNAs could contribute to reverse chemoresistance of pancreatic cancer cells. We hope this review might stimulate the studies of lncRNAs and cicrRNAs, and develop the new therapeutic strategy via modulating these noncoding RNAs to promote chemosensitivity of pancreatic cancer cells.

由于缺乏早期症状、转移发生和化疗耐药性，胰腺癌是世界上最常见的癌症死亡原因之一。因此，通过检测生物标志物进行早期诊断、阻断转移、克服化疗耐药是提高胰腺癌患者生存率的有效策略。越来越多的证据表明，长链非编码 RNA (lncRNA) 和环状 RNA (circRNA) 在调节胰腺癌的化学敏感性方面发挥着重要作用。在这篇综述文章中，我们将总结lncRNAs在胰腺癌细胞耐药中的作用，包括HOTTIP、HOTAIR、PVT1、linc-ROR、GAS5、UCA1、DYNC2H1-4、MEG3、TUG1、HOST2、HCP5、SLC7A11-AS1和 CASC2。我们还强调了 circRNA 的功能，例如 circHIPK3 和 circ_0000284，调节胰腺癌细胞的药物敏感性。此外，我们描述了许多化合物，包括姜黄素、染料木黄酮、白藜芦醇、槲皮素和盐霉素，它们可以调节 lncRNA 的表达并增强胰腺癌的化学敏感性。因此，靶向特定的 lncRNA 和 cicrRNA 可能有助于逆转胰腺癌细胞的化学抗性。我们希望这篇综述可以激发对 lncRNA 和 cicrRNA 的研究，并通过调节这些非编码 RNA 来促进胰腺癌细胞的化学敏感性开发新的治疗策略。靶向特定的 lncRNA 和 cicrRNA 可能有助于逆转胰腺癌细胞的化学抗性。我们希望这篇综述可以激发对 lncRNA 和 cicrRNA 的研究，并通过调节这些非编码 RNA 来促进胰腺癌细胞的化学敏感性开发新的治疗策略。靶向特定的 lncRNA 和 cicrRNA 可能有助于逆转胰腺癌细胞的化学抗性。我们希望这篇综述可以激发对 lncRNA 和 cicrRNA 的研究，并通过调节这些非编码 RNA 来促进胰腺癌细胞的化学敏感性开发新的治疗策略。