The innate and inducible resistance of six Salmonella strains (4/74, FS8, FS115, P167807, ATCC 13076, WT) in mayonnaise at 5 °C following adaptation to different pH/undissociated acetic acid (UAA) combinations (15mM/pH5.0, 35mM/pH5.5, 45mM/pH6.0) was investigated. The inherent and acid-induced responses were strain-dependent. Two strains (ATCC 13076, WT), albeit not the most resistant innately, exhibited the most prominent adaptive potential. Limited/no adaptability was observed regarding the rest strains, though being more resistant inherently. The individual effect of pH and UAA adaptation in the phenotypic and transcriptomic profiles of ATCC 13076 and WT was further examined. The type (pH, UAA) and magnitude of stress intensity affected their responses. Variations in the type and magnitude of stress intensity also determined the relative gene expression of four genes (adiA, cadB, rpoS, ompR) implicated in Salmonella acid resistance mechanisms. adiA and cadB were overexpressed following adaptation to some treatments; rpoS and ompR were downregulated following adaptation to 15mM/pH5.0 and 35mM/pH5.5, respectively. Nonetheless, the transcriptomic profiles did not always correlate with the corresponding phenotypes. In conclusion, strain variations in Salmonella are extensive. The ability of the strains to adapt and induce resistant phenotypes and acid resistance-related genes is affected by the type and magnitude of the stress applied during adaptation.

六种沙门氏菌的先天性和诱导性抗性适应不同pH /未解离的乙酸（UAA）组合（15mM / pH5.0、35mM / pH5.5、45mM）后，在5°C的蛋黄酱中于5°C的菌株（4/74，FS8，FS115，P167807，ATCC 13076，WT） /pH6.0）。固有和酸诱导的响应是应变依赖性的。尽管天生不是最强的抗性，但两个菌株（ATCC 13076，WT）表现出最突出的适应性。关于其余菌株，观察到有限/没有适应性，尽管其固有地更具抗性。进一步检查了pH和UAA适应性在ATCC 13076和WT的表型和转录组谱中的个体作用。压力强度的类型（pH，UAA）和强度会影响其响应。应激强度类型和强度的变化也决定了四个基因的相对基因表达（adiA，cadB，rpoS，ompR）与沙门氏菌的抗酸性有关。在适应某些治疗后，adiA和cadB过表达；分别适应15mM / pH5.0和35mM / pH5.5后，rpoS和ompR分别下调。尽管如此，转录组谱并不总是与相应的表型相关。总之，沙门氏菌的菌株差异很大。菌株适应和诱导抗性表型和耐酸相关基因的能力受适应过程中施加的压力的类型和大小影响。