Abstract Glycopolymers are synthetic polymers, containing sugar groups on their pendant chains. They have been widely investigated for various biological and biomedical applications due to excellent hydrophilicity, biodegradability, and biocompatibility. Glycopolymers can mimic the biological functions of glycan in recognition processes through multivalent lectin interactions. Stimuli-responsive polymers such as thermo-responsive, pH-responsive, and light-responsive materials have also attracted much attention in biomedical applications. By incorporation of responsive chains in glycopolymers, they can be responsive to the changes in their surrounding medium. Moreover, this combination provides materials with selective binding to specific cells and the ability to enhance and control the lectin-polymer interactions effectively and selectively with changes in the surrounded environment. These smart glycopolymers have potential applications in the biomedical field and targeted drug delivery systems. Various investigations and research have been done to design novel polymeric systems with enhanced properties. This review mainly highlights the progress done in recent years on stimuli-responsive glycopolymers primarily focusing on mostly used (thermo, pH, and light) stimuli-responsive glycopolymers and their applications.

中文翻译：

---

刺激响应性糖聚合物及其生物学应用

摘要 糖基聚合物是合成聚合物，在其侧链上含有糖基团。由于优异的亲水性、生物降解性和生物相容性，它们已被广泛研究用于各种生物和生物医学应用。糖聚合物可以通过多价凝集素相互作用在识别过程中模拟聚糖的生物学功能。刺激响应聚合物如热响应、pH 响应和光响应材料在生物医学应用中也引起了广泛关注。通过在糖聚合物中加入响应链，它们可以响应周围介质的变化。而且，这种组合为材料提供了与特定细胞选择性结合的能力，并能够有效地、选择性地增强和控制凝集素-聚合物相互作用，以适应周围环境的变化。这些智能糖聚合物在生物医学领域和靶向药物输送系统中具有潜在应用。已经进行了各种调查和研究来设计具有增强性能的新型聚合物系统。这篇综述主要强调了近年来在刺激响应性糖聚合物方面取得的进展，主要关注最常用的（热、pH 和光）刺激响应性糖聚合物及其应用。已经进行了各种调查和研究来设计具有增强性能的新型聚合物系统。这篇综述主要强调了近年来在刺激响应性糖聚合物方面取得的进展，主要关注最常用的（热、pH 和光）刺激响应性糖聚合物及其应用。已经进行了各种调查和研究来设计具有增强性能的新型聚合物系统。这篇综述主要强调了近年来在刺激响应性糖聚合物方面取得的进展，主要关注最常用的（热、pH 和光）刺激响应性糖聚合物及其应用。