Liquid nanovehicles are gaining interest in drug delivery because of the high solubilization capacity of bioactives at their interface and enhanced permeation of compounds across physiological membranes. However, the dermal application of liquid nanovehicles is still limited. The goal of this research is to develop a dermal delivery system based on embedding of liquid nanovehicles into polymeric films, which will allow controlled release of the nanodroplets with the solubilized drug.

In this study, we describe the incorporation of empty and curcumin-loaded nanodomains into polymeric film. The novel technology results in formation of homogeneous, transparent and elastic films with high (up to 85 wt%) loading capacity of nanodomains. The fundamental structural characterizations show that nanodomain structures embedded in the dry film are spontaneously reformed during the dermal application with similar droplets size of 10 nm. Ex-vivo release studies were performed on Franz diffusion cells and demonstrated a significant permeation of curcumin through the pig skin.

This novel film technology can serve as a "solid platform reservoir" for liquid nanovehicles which enables controlled release of nanodroplets with solubilized bioactive.

由于生物活性物质在其界面处的高溶解能力和增强的化合物跨生理膜的渗透性，液体纳米载体在药物递送方面引起了人们的兴趣。然而，液体纳米车辆的皮肤应用仍然受到限制。这项研究的目标是开发一种基于将液态纳米载体嵌入聚合物膜中的皮肤递送系统，该系统将允许通过溶解的药物控制纳米滴的释放。

在这项研究中，我们描述了将空的和姜黄素加载的纳米域合并到聚合物膜中。这项新技术可形成具有高（高达85 wt％）纳米域负载能力的均匀，透明和弹性的薄膜。基本的结构特征表明，在皮肤应用过程中，嵌入干膜中的纳米域结构会自发地重新形成，液滴大小相似，为10 nm。在Franz扩散细胞上进行了离体释放研究，结果表明姜黄素可通过猪皮肤大量渗透。

这项新颖的薄膜技术可以用作液体纳米车辆的“固体平台储存器”，从而可以控制释放具有溶解的生物活性物质的纳米液滴。