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Relationship between the Porous Structure Hierarchy and the Physical and Mechanical Properties of Calcium Phosphate Drug Carriers
Russian Physics Journal ( IF 0.6 ) Pub Date : 2020-11-01 , DOI: 10.1007/s11182-020-02151-y
E. G. Komarova , M. B. Sedelnikova , E. A. Kazantseva , P. V. Uvarkin , Yu. P. Sharkeev

A relationship between the structural-morphological and physical-mechanical properties of macro-porous calcium phosphate (CaP) coatings on the surface of titanium implants is studied. The produced CaP coatings can be used as carriers for target drug delivery in biomedical applications. The regularities of the formation of bulk (thickness of 15–130 μm) and rough (Ra = 1.7–8.5 μm) CaP coatings deposited by the micro-arc oxidation (MAO) method are studied. The coatings have a hierarchical porous structure and a uniform distribution of the structural elements (spheres and pores) over the surface. Correlations between the value of the applied voltage and structural-morphological and physical-mechanical characteristics of the CaP coatings have been established. The value of the coating adhesion strength has been determined with tensile tests. Both cohesive and mixed adhesive-cohesive pull-off of the MAO coating from the substrate have been identified.

中文翻译:

磷酸钙药物载体的多孔结构层次与物理机械性能的关系

研究了钛植入物表面大孔磷酸钙 (CaP) 涂层的结构-形态和物理-机械性能之间的关系。生产的 CaP 涂层可用作生物医学应用中靶向药物递送的载体。研究了通过微弧氧化(MAO)方法沉积的块状(厚度为 15-130 μm)和粗糙(Ra = 1.7-8.5 μm)CaP 涂层的形成规律。涂层具有分级多孔结构和结构元素(球体和孔)在表面上的均匀分布。已经建立了施加电压值与 CaP 涂层的结构形态和物理机械特性之间的相关性。涂层粘附强度的值已通过拉伸试验确定。
更新日期:2020-11-01
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