Abstract

Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweed Undaria pinnatifida treatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation. U. pinnatifida administration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity. U. pinnatifida intake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects of U. pinnatifida on high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such as Bacteroides acidifaciens and Bacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management.

Key points

• U. pinnatifida improved adipose accumulation and lipid metabolism.

• B. acidifaciens and B. ovatus contributed to the beneficial effects of U. pinnatifida.

• SCFAs and TCA cycle intermediates were critical to the metabolic outcomes.

• Our study provides a cheap dietary strategy for obesity management.

中文翻译：

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裙带菜（Undaria pinnatifida）与高脂饮食喂养小鼠的肠道菌群和代谢组学调控相关联，改善了与肥胖相关的结果

摘要

膳食纤维对肥胖相关疾病和肠道菌群具有有益作用，在膳食代谢和宿主代谢之间的相互作用中起关键作用。我们的目的是研究高脂饮食喂养的小鼠用紫菜裙带菜处理能改善多种生理状态的原因，并评估其随后的抗肥胖和降血脂作用是否与肠道菌群及其相关性有关。代谢组学调控。在我们的实验中，使用pinnatifida可以显着降低高脂饮食诱导的体重增加，以及附睾和腹部肥胖。pinnatifida摄入还可以显着减少肝脏重量和血清三酰甘油的积累。我们还发现，pinnatifida对高脂饮食诱导的代谢功能障碍的改善作用与特定细菌（例如酸化拟杆菌和卵形拟杆菌）以及代谢产物（包括短链脂肪酸和三羧酸）的显着增加有关循环中间体。我们的结果提供了一种廉价的饮食策略来控制新陈代谢和肥胖管理。

关键点

• Pinnatifida改善了脂肪积累和脂质代谢。

• B. acidifaciens和B. ovatus有助于pinnatifida的有益作用。

• SCFA和TCA循环中间体对代谢结果至关重要。

•我们的研究为肥胖管理提供了廉价的饮食策略。