Wound healing is a complex and sequential biological process that involves multiple stages. Current treatments for nonhealing or chronic wounds are unsatisfactory as they exert a single effect on one specific activity. Herein, we constructed a silver nanowire (AgNW)-based, three-dimensional (3D), porous foam dressing that is flexible and conductive. This conductive foam dressing was composed of AgNWs modified with a stable hydrophobic coating and porous polyurethane (PU), providing a skeleton to support the 3D conductive networks. The AgNWs-PU foam dressing exhibited favorable biocompatibility, outstanding electrical properties, excellent bending-compression durability, and long-term stability under wet conditions, making it suitable for wound treatment. Via the conductive foam dressing, negative pressure and exogenous wound directional electric fields (EFs) could be integrated for simultaneous implementation, and the artificial jointly constructed microenvironment promoted wound healing in a system. This novel “all-in-one” device presented intrinsic multifunctionality, including the drainage of pus and necrotic tissue, mitigation of inflammation, promotion of cell proliferation, direction of keratinocyte migration, and induction of angiogenesis. An immunohistochemical assay and western blot analysis illustrated that the angiogenesis and cell proliferation pathways in the tissue were significantly activated when this novel therapy was adopted. More importantly, the practical performance of this “all-in-one” device was demonstrated by assessment of full-thickness defect wounds in model pigs. Comparing the percentage of residual wound area after administration of traditional treatment (25.82 ± 3.52%) and the novel treatment (3.07 ± 1.23%) demonstrated the promising applications of this novel treatment in clinical wound healing.

中文翻译：

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通过柔性多孔导电敷料整合负压和外源电场来优化微环境，从而加速伤口愈合

伤口愈合是一个复杂而连续的生物学过程，涉及多个阶段。目前，对于不愈合或慢性伤口的治疗方法并不令人满意，因为它们仅对一种特定的活性起作用。在本文中，我们构建了基于银纳米线（AgNW）的三维（3D）多孔泡沫敷料，该敷料具有柔性和导电性。该导电泡沫敷料由经过稳定疏水涂层改性的AgNW和多孔聚氨酯（PU）组成，可提供支撑3D导电网络的骨架。AgNWs-PU泡沫敷料具有良好的生物相容性，出色的电性能，优异的弯曲压缩耐久性以及在潮湿条件下的长期稳定性，使其适合伤口处理。通过导电泡沫敷料，负压和外源性伤口定向电场（EFs）可以集成在一起同时实施，而人工联合构建的微环境可以促进系统中的伤口愈合。这种新颖的“多合一”设备具有固有的多功能性，包括引流脓液和坏死组织，减轻炎症，促进细胞增殖，角质形成细胞迁移的方向以及诱导血管生成。免疫组织化学测定和蛋白质印迹分析表明，采用这种新疗法后，组织中的血管生成和细胞增殖途径被显着激活。更重要的是，通过评估模型猪的全层缺损伤口，证明了这种“多合一”装置的实用性能。