Tonsils are believed to be the initial site of the John Cunningham virus (JCV) infection. The long-term effect of childhood tonsillectomy on JCV status in multiple sclerosis (MS) patients has not been investigated. In this retrospective case-control study, we analyzed data of 144 JCV seropositive cases and 82 JCV seronegative controls from three outpatient MS clinics in the United States. Early tonsillectomy (before the age of 8) was reported among 8 (5.56%) JCV seropositive subjects and 19 (23.17%) controls. Early tonsillectomy was associated with JCV negative status (adjusted odds ratio = 5.39, 95% confidence interval = 2.13-13.62, p < 0.001) independent of age and gender.

中文翻译：

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扁桃体切除术对多发性硬化患者 John Cunningham 病毒血清学状态的影响：一项回顾性病例对照研究

扁桃体被认为是约翰·坎宁安病毒 (JCV) 感染的初始部位。尚未研究儿童扁桃体切除术对多发性硬化症 (MS) 患者 JCV 状态的长期影响。在这项回顾性病例对照研究中，我们分析了来自美国三个门诊 MS 诊所的 144 名 JCV 血清阳性病例和 82 名 JCV 血清阴性对照的数据。在 8 名 (5.56%) JCV 血清阳性受试者和 19 名 (23.17%) 对照组中报告了早期扁桃体切除术（8 岁之前）。早期扁桃体切除术与 JCV 阴性状态相关（调整后的比值比 = 5.39，95% 置信区间 = 2.13-13.62，p < 0.001），与年龄和性别无关。