当前位置: X-MOL 学术Exp. Biol. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
Experimental Biology and Medicine ( IF 3.2 ) Pub Date : 2020-11-12 , DOI: 10.1177/1535370220968752
Sandra Kraljević Pavelić 1 , Vedran Micek 2 , Dragica Bobinac 3, 4, 5 , Edo Bazdulj 3, 4 , Alessandra Gianoncelli 6 , Dalibor Krpan 7 , Marta Žuvić 8 , Sandra Eisenwagen 9 , Peter J Stambrook 10 , Krešimir Pavelić 5
Affiliation  

The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their anti-fracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.



中文翻译:

用改性沸石治疗骨质疏松症在骨质疏松大鼠模型和人体临床试验中显示出有益效果

人类骨质疏松症的严重性表现在其高发病率和降低生活质量的并发症。骨质疏松症的一个社会后果是它给患者及其家人带来了沉重的负担。已经为骨质疏松症患者开了几种骨修饰药物。然而,其抗骨折功效的证据仍无定论。相反,长期使用抗骨质疏松药物如双膦酸盐和 RANKL 抑制剂狄诺塞麦会导致不良事件。我们现在提出一种治疗骨质疏松症的替代和辅助方法。数据来自体内在去卵巢大鼠模型和随机双盲、安慰剂对照的人类临床研究中进行的研究。这两项研究都涉及用 Panaceo 微活化 (PMA)-沸石-斜发沸石处理,这是一种确定的阳离子交换斜发沸石,它明显改善了从去卵巢动物身上检查的所有骨组织形态学参数,表明骨形成增加。此外,PMA-沸石-斜发沸石干预一年被证明对人类是安全的。此外,与对照组(安慰剂)组患者相比,接受 PMA-沸石-斜发沸石治疗的患者骨密度增加,骨形成标志物水平升高,疼痛显着减轻,生活质量显着提高.

更新日期:2020-11-13
down
wechat
bug