An efficient synthesis of nucleoside 5'-monothiophosphates under mild reaction conditions using commercially available thiophosphoryl chloride was achieved with a cinchona alkaloid catalyst. A detailed mechanistic study of the reaction was undertaken, employing a combination of reaction kinetics, NMR spectroscopy, and computational modeling, to better understand the observed reactivity. Taken collectively, the results support an unprecedented mechanism for this class of organocatalyst.

中文翻译：

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金鸡纳生物碱催化的新机制允许有效的硫代磷酸化反应

使用金鸡纳生物碱催化剂，在温和的反应条件下，使用市售的硫代磷酰氯高效合成核苷 5'-单硫代磷酸酯。对该反应进行了详细的机理研究，结合了反应动力学、核磁共振光谱和计算模型，以更好地了解观察到的反应性。总的来说，结果支持此类有机催化剂的前所未有的机制。