Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago–miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.

中文翻译：

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哺乳动物Argonaute2功能的新见解

揭示识别microRNA（miRNA）靶标的机制是最大的挑战之一，因为当结合靶标时，Ago-miRNA复合物能够克服互补性的不同减损。但是，最近解决的Argonaute2（Ago2）晶体结构和使用重新设计的测序技术进行的高通量分析使我们更接近实现这一目标。