Objectives: To evaluate the effects of nuclear magnetic resonance therapy (MBST®) on the clinical symptoms of osteoarthritis (OA) in the elbow joints of dogs.

Methods: In this double-blind study, 28 dogs with lameness caused by OA in the elbow joint were randomly allocated to two groups: 14 dogs received nuclear magnetic resonance (NMR) therapy [treatment group (TG)], and 14 dogs received a placebo [placebo group (PG)] over a period of 7 consecutive days. Visual and objective gait analyses were performed before treatment (M1) and at 3 (M2) and 6 months (M3) after treatment. At M2 and M3 Symmetry indices (SI) of the peak vertical force (PVFz) and the vertical impulse (IFz), lameness scores, and pain scores were compared with their values at M1 to calculate the overall treatment effectiveness (OTE) score. We also documented additional pain medication and medical physiotherapy during the time of study. Finally, we measured the range of motion (ROM) in order to evaluate the functional development of the joint.

Results: The median OTE score of dogs in the TG indicates no change after 3 month and was improved after 6 months of treatment. There was an improvement of the median OTE score of dogs in the PG after 3 months of treatment. Further, the OTE scores of dogs in the PG were actually worse after 6 months.

Nevertheless, there were no significance differences in SIPVFz, SIIFz, ROM, and lameness- and pain scores between the TG and PG at M1, M2, and M3. When considering all collected parameters (excluding the ROM) to calculate the OTE, no significant difference between groups was measurable for the OTE.

Conclusion: There was a positive effect of NMR therapy (MBST®) on the treatment of OA in dogs. However, future studies should investigate the mechanisms underlying NMR therapy and the pathophysiology of OA to provide optimal treatments for patients.

Clinical Significance: Our results demonstrated that the response to NMR treatment was individualized for each dog. As an integral way of treating dogs with chronic OA, NMR therapy may be an alternative therapeutic approach to support traditional medications.

目标： 评估核磁共振疗法（MBST®）对狗肘关节骨关节炎（OA）临床症状的影响。

方法：在这项双盲研究中，将28只因OA引起的肘关节la行的狗随机分为两组：14只狗接受了核磁共振（NMR）治疗[治疗组（TG）]，而14只狗接受了安慰剂[连续7天服用安慰剂组（PG）]。在治疗前（M1），治疗后3（M2）和6个月（M3）进行视觉和客观步态分析。在M2和M3处，将峰值垂直力（PVFz）和垂直冲量（IFz）的对称性指数（SI）与1足评分和疼痛评分与其在M1处的值进行比较，以计算总体治疗效果（OTE）评分。在研究期间，我们还记录了其他止痛药和药物物理疗法。最后，我们测量了运动范围（ROM），以评估关节的功能发展。

结果：TG中犬的OTE得分中位数表明3个月后无变化，治疗6个月后有所改善。治疗3个月后，PG中犬的OTE得分中位数有所改善。此外，PG中的狗的OTE得分在6个月后实际上更差。

但是，在M1，M2和M3时，TG和PG之间的SIPVFz，SIIFz，ROM和la行和疼痛评分没有显着差异。当考虑所有收集的参数（不包括ROM）以计算OTE时，对于OTE而言，组之间没有显着差异。

结论：NMR治疗（MBST®）对狗的OA有积极作用。但是，未来的研究应研究NMR治疗的基础机制和OA的病理生理机制，以便为患者提供最佳治疗。

临床意义：我们的结果表明，每只狗对NMR治疗的反应是个体化的。作为治疗慢性OA犬的必不可少的方法，NMR治疗可能是支持传统药物的另一种治疗方法。