Abstract Many alternatives are under investigation since 2006 when the European Union banned the use of antimicrobials in animal feed. The objective of this study was to find the effect of different feed additives in comparison with antibiotic on the performance and gut health in broiler infected with Salmonella during the starter phase. A total of 240 one day old male Ross 308 chickens were divided into six groups as follow: control treatment (negative control), orally challenged with Salmonella enterica subsp. Typhimurium (positive control), T1: oral challenge + 0.1 g/kg antibiotic, T2: oral challenge + 0.15 g/kg Sanguinarine, T3: oral challenge + 1 g/kg oregano powder, T4: oral challenge + calcium montmorillonite. On day second of the experiment, challenge was performed at a dose rate of 1.0 mL of the inoculum (4.5 × 108 CFU/mL). Data were statistically analysed with the help of Analysis of Variance (ANOVA) for repeated measures using least significant difference (LSD) as post-hoc test. Feed consumption was significantly (p < .01) improved in both positive and negative control groups and significantly lower in the other treatment groups. Significantly (p < .01) lower body weight was found in positive control, T3 and T4. Improved feed conversion ratio (FCR) was recorded in T2 and the control groups. Production Efficiency Factor (PEF) was significantly (p < .05) lower in positive control T2 and negative control. Villus surface area did not differ significantly (p > .05) between the control and experimental groups. Significantly (p < .01) higher villus width was found in T1, T4 and negative control. Similarly, villus height was higher (p < .05) in T2 and T4 compared to the control. It was concluded from the present study that different natural feed additives produced promising results in term of improved growth traits and gut health in Salmonella infected broilers. However, Sangrovit Extra produced better results in comparison with other treatments. HIGHLIGHTS Body weight, feed efficiency were improved in Sangrovit Extra fed broiler. Production efficiency factor was enhanced in Sangrovit Extra fed broiler. Villus height was significantly higher in Sangrovit Extra fed broiler. Villus width was enhanced in antibiotic treated broiler.

中文翻译：

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饲料中添加一些天然产物对沙门氏菌感染肉鸡的生产性能和育雏期肠道损伤的影响

摘要 自 2006 年欧盟禁止在动物饲料中使用抗菌素以来，许多替代品正在研究中。本研究的目的是发现与抗生素相比，不同饲料添加剂对感染沙门氏菌的肉鸡的生产性能和肠道健康的影响。总共240只一日龄雄性Ross 308鸡被分成如下六组：对照处理（阴性对照），用肠沙门氏菌亚种口服攻击。鼠伤寒杆菌（阳性对照），T1：口服激发 + 0.1 g/kg 抗生素，T2：口服激发 + 0.15 g/kg 血根碱，T3：口服激发 + 1 g/kg 牛至粉，T4：口服激发 + 蒙脱石钙。在实验的第二天，以 1.0 mL 接种物 (4.5 × 108 CFU/mL) 的剂量率进行攻击。借助方差分析 (ANOVA) 对数据进行统计分析，以使用最小显着差异 (LSD) 作为事后检验进行重复测量。阳性和阴性对照组的饲料消耗量显着提高（p < .01），而其他处理组的饲料消耗量显着降低。在阳性对照、T3 和 T4 中发现显着 (p < .01) 较低的体重。在 T2 和对照组中记录了改进的饲料转化率 (FCR)。生产效率因子 (PEF) 在阳性对照 T2 和阴性对照中显着降低 (p < .05)。绒毛表面积在对照组和实验组之间没有显着差异（p > .05）。在 T1、T4 和阴性对照中发现显着 (p < .01) 更高的绒毛宽度。同样，绒毛高度更高（p < . 05) 在 T2 和 T4 中与对照相比。本研究得出的结论是，不同的天然饲料添加剂在改善感染沙门氏菌的肉鸡的生长性状和肠道健康方面产生了可喜的结果。然而，与其他治疗方法相比，Sangrovit Extra 产生了更好的结果。亮点 Sangrovit Extra 饲喂肉鸡的体重和饲料效率得到改善。Sangrovit Extra 饲喂肉鸡的生产效率系数得到提高。Sangrovit Extra饲喂肉鸡的绒毛高度显着更高。抗生素处理的肉鸡的绒毛宽度增加。与其他治疗方法相比，Sangrovit Extra 产生了更好的结果。亮点 Sangrovit Extra 饲喂肉鸡的体重和饲料效率得到改善。Sangrovit Extra 饲喂肉鸡的生产效率系数得到提高。Sangrovit Extra饲喂肉鸡的绒毛高度显着更高。抗生素处理的肉鸡的绒毛宽度增加。与其他治疗方法相比，Sangrovit Extra 产生了更好的结果。亮点 Sangrovit Extra 饲喂肉鸡的体重和饲料效率得到改善。Sangrovit Extra 饲喂肉鸡的生产效率系数得到提高。Sangrovit Extra饲喂肉鸡的绒毛高度显着更高。抗生素处理的肉鸡的绒毛宽度增加。