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Coronary Heart Disease and Atrial Fibrillation: A Vicious cycle
American Journal of Physiology-Heart and Circulatory Physiology ( IF 4.8 ) Pub Date : 2020-11-13 , DOI: 10.1152/ajpheart.00702.2020
Feng Liang 1, 2 , Yi Wang 1
Affiliation  

The population suffering from coronary heart disease (CHD) complicated by atrial fibrillation (AF) is rising rapidly. A strong correlation between the two diseases has been reported, and the many common risk factors they share may play prominent roles in their development. In addition, CHD can directly promote the progression of AF by affecting reentry formation, focal ectopic activity and neural remodeling. At the same time, AF also affects CHD through three aspects: atherosclerosis, the mismatch of blood supply and oxygen consumption, and thrombosis. In conclusion, CHD and AF can aggravate each other and seem to form a vicious cycle. For patients with CHD complicated by AF, principal studies and guidelines have focused on antithrombotic treatment and rhythm control, which are paramount for these patients. Of note, our review sheds light on the strategies to break the cycle of the two diseases, which may be fundamental to treat these patients and optimize the benefit.

中文翻译:

冠心病和心房颤动:恶性循环

患有冠心病(CHD)并发房颤(AF)的人口正在迅速增加。据报道,这两种疾病之间存在很强的相关性,它们共享的许多常见危险因素可能在其发展中发挥重要作用。此外,冠心病可通过影响折返形成,局灶性异位活动和神经重塑直接促进房颤的发展。同时,AF还通过三个方面影响冠心病:动脉粥样硬化,血液供应和氧气消耗的不匹配以及血栓形成。总之,冠心病和房颤可以加重,似乎形成了恶性循环。对于伴有房颤的冠心病患者,主要研究和指南集中在抗血栓治疗和节律控制上,这对于这些患者而言至关重要。值得注意的是
更新日期:2020-11-13
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