Load, chamber stiffness, and relaxation are the three established determinants of global diastolic function (DF). Coupling of systolic stiffness and isovolumic relaxation has been hypothesized, however, diastolic stiffness-relaxation coupling (DSRC) remains unknown. The parametrized diastolic filling (PDF) formalism, a validated DF model incorporates DSRC. PDF model-predicted DSRC was validated by analysis of 159 Doppler E-waves from a published dataset (22 healthy volunteers undergoing bicycle exercise). E-waves at varying (46-120 bpm) heart rates (HR) demonstrated variation in acceleration time (AT), deceleration time (DT), and E-wave peak velocity. AT, DT, E_peak were converted into PDF parameters: stiffness (), relaxation (), and load (x_o) using published numerical methods. Univariate linear regression showed that over a two-fold increase in HR, AT and DT decrease ( = -0.44; p < 0.001 and -0.42; p < 0.001, respectively), while, DT/AT remains constant (; p = 0.67). Similarly, increases with HR (; p < 0.001) while has no significant correlation with HR (; p = 0.32). However, the dimensionless DSRC parameter shows no significant correlation with HR (; p = 0.7). Furthermore, is uniquely determined by DT/AT rather than AT or DT independently. Constancy of in spite of a two-fold increase in HR establishes that stiffness (k) and relaxation (c) are coupled and manifest via a HR-invariant parameter of E-wave asymmetry and should not be considered independent of each other. The manifestation of DSRC through E-wave asymmetry via underscores the value of DT/AT as a physiologic, mechanism-derived index of DF.

中文翻译：

---

电子波不对称阐明了舒张期心室刚度-舒张耦合：体内验证基于模型的预测。

负荷，房室僵硬和松弛是整体舒张功能（DF）的三个确定的决定因素。已经假设了收缩期刚度和等容松弛的耦合，但是，舒张期刚度松弛耦合（DSRC）仍然未知。参数化舒张压填充（PDF）形式主义，一种经过验证的DF模型结合了DSRC。PDF模型预测的DSRC通过分析已发布数据集中的159个多普勒E波进行了验证（22位健康的自行车运动志愿者）。心率（HR）处于变化（46-120 bpm）的电子波显示出加速时间（AT），减速时间（DT）和电子波峰值速度的变化。将AT，DT，E_峰转换为PDF参数：刚度（），松弛（）和负载（x _o）使用公开的数值方法。单变量线性回归显示，HR，AT和DT降低两倍以上（分别为-0.44； p <0.001和-0.42； p <0.001），而DT / AT保持恒定（; p = 0.67） 。同样，随着HR（; p <0.001）的增加而与HR（; p = 0.32）没有显着相关性。但是，无量纲的DSRC参数与HR无关（p = 0.7）。此外，由DT / AT唯一地确定，而不是由AT或DT独立地确定。尽管HR增加了两倍，但常数却表明，刚度（k）和松弛（c）是通过E波不对称性的HR不变参数耦合并表现出来的，因此不应视为彼此独立。DSRC通过E波不对称性的表现强调了DT / AT作为生理学，