Under normal conditions, coronary blood flow (CBF) provides critical blood supply to the myocardium so that it can appropriately meet the metabolic demands of the body. Dogmatically, there exist several known regulators and modulators of CBF that include local metabolites and neurohormonal factors that can influence the function of the coronary circulation. In disease states such as diabetes and myocardial ischemia, these regulators are impaired or shifted such that CBF is reduced. While functional considerations have and continued to be well studied, more recent evidence builds upon established studies that collectively suggest that the relative roles of coronary structure, biomechanics, and the influence of cardiac biomechanics via extravascular compression may also play a significant role in dictating CBF. In this mini review, we discuss these regulators of CBF under normal and pathophysiological conditions and their potential influence on the control of CBF.

中文翻译：

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冠状动脉重塑和生物力学：2020 年我们会顺其自然吗？

在正常情况下，冠状动脉血流（CBF）为心肌提供了关键的血液供应，使其能够适当地满足身体的代谢需求。从教条上讲，存在几种已知的 CBF 调节剂和调节剂，包括可影响冠状动脉循环功能的局部代谢物和神经激素因子。在糖尿病和心肌缺血等疾病状态下，这些调节剂受损或发生移位，从而导致 CBF 降低。虽然功能方面的考虑已经并继续得到很好的研究，但最近的证据建立在既定研究的基础上，这些研究共同表明冠状动脉结构、生物力学的相对作用以及通过血管外压迫对心脏生物力学的影响也可能在决定 CBF 中发挥重要作用。在这个迷你评论中，