Airway hyper‐responsiveness and persistent airflow obstruction contribute to asthma pathogenesis and symptoms, due in part to airway smooth muscle (ASM) hypercontractility and increased ASM mass. Fibrocytes have been shown to localise to the ASM in asthma however it is not known whether fibrocytes localise to the ASM in nonasthmatic eosinophilic bronchitis (NAEB) and chronic obstructive pulmonary disease (COPD). In addition, the potential consequences of fibrocyte localisation to ASM as regards asthma pathophysiology has not been widely studied.

中文翻译：

---

哮喘中纤维细胞定位于 ASM 束：对细胞表型和行为的双向影响

气道高反应性和持续气流阻塞有助于哮喘发病机制和症状，部分原因是气道平滑肌 (ASM) 过度收缩和 ASM 质量增加。已显示纤维细胞在哮喘中定位于 ASM，但尚不清楚在非哮喘性嗜酸性支气管炎 (NAEB) 和慢性阻塞性肺病 (COPD) 中纤维细胞是否定位于 ASM。此外，关于哮喘病理生理学，纤维细胞定位到 ASM 的潜在后果尚未得到广泛研究。