Whilst reduced signalling and gene expression related to gamma‐aminobutyric acid (GABA) play a role in the presumed pathophysiology of schizophrenia, its origin is unclear. Studying asymptomatic individuals with high genetic liability to schizophrenia (AIs) would provide insights. Therefore, this study aimed to investigate the role of genetic liability in GABAergic dysfunction of schizophrenia by exploring in vivo GABA‐A/benzodiazepine receptor (GABAR) availability in AIs.

中文翻译：

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精神分裂症高遗传负荷无症状个体的体内γ-氨基丁酸-A/苯二氮卓受体可用性和遗传易感性：[11C]氟马西尼正电子发射断层扫描研究

虽然与 γ-氨基丁酸 (GABA) 相关的信号传导和基因表达减少在精神分裂症的假定病理生理学中发挥作用，但其起源尚不清楚。研究对精神分裂症 (AI) 具有高度遗传倾向的无症状个体将提供见解。因此，本研究旨在通过探索AIs体内GABA-A/苯二氮卓受体 (GABAR) 的可用性来研究遗传易感性在精神分裂症 GABA 能功能障碍中的作用。