A mock video game of pandemic outbreaks illustrates how scientists around the globe with various resources are tackling missions in the combat against Covid‐19. In their full paper, S. H. L. Verhelst et al. describe the development of an activity‐based probe to selectively detect the active Main protease of SARS‐CoV2. This probe is armed with a cysteine‐reactive acyloxymethyl ketone warhead and a substrate‐based peptide skeleton that allow it to detect the protease even in a complex human proteome.

中文翻译：

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肽基酰氧基甲基酮是SARS-CoV-2主要蛋白酶的基于活性的探针

一个模拟的大流行病视频游戏说明了全球科学家如何利用各种资源来应对针对Covid-19的任务。S.H.L.Verhelst等人的论文全文。描述了基于活性的探针的开发，以选择性检测SARS-CoV2的活性主蛋白酶。该探针配有半胱氨酸反应性酰氧基甲基酮战斗部和基于底物的肽骨架，即使在复杂的人类蛋白质组中也能检测到蛋白酶。