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Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine‐Based Palladacycle
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-11-12 , DOI: 10.1002/anie.202014141
Balaram S. Takale 1 , Ruchita R. Thakore 1 , Gianluca Casotti 1, 2 , Xaiohan Li 1 , Fabrice Gallou 3 , Bruce H. Lipshutz 1
Affiliation  

An inexpensive and new triphenylphosphine‐based palladacycle has been developed as a pre‐catalyst, leading to highly effective Stille cross‐coupling reactions in water under mild reaction conditions. Only 500–1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij‐30 in water.

中文翻译:

使用基于三苯基膦的Palladacycle的百万分之几的含量在水中进行轻度和鲁棒的Stille反应

已经开发出一种廉价的新型三苯基膦基戊二环作为预催化剂,可在温和的反应条件下在水中进行高效的Stille交叉偶联反应。仅500-1000 ppm的Pd足以用于涉及各种芳基/杂芳基卤化物与芳基/杂芳基锡烷的偶联。使用这种催化剂,可以在由2 wt%Brij-30在水中形成的水​​性纳米反应器中制备几种药物中间体。
更新日期:2020-11-12
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