Biofluorescence in living entities is a functional process associated with information conveyance; whereas the capacity to respond to internal physiological signals is a unique property of a cell. By integrating these two biological features into materials design, a bioinspired material, namely CPS, is developed. Contrary to conventional luminescent polymeric systems whose emission comes from π‐conjugated structures, this material displays clusterization‐triggered emission. In the preclinical trial on a dermal punch model of tissue repair, it successfully increases the rate of wound closure, reduces inflammatory cell infiltration, and enhances collagen deposition. It can also relay changes in internal chemical signals into changes in its intrinsic luminescence for biphasic chemical sensing to prevent possible occurrence of skin hyperpigmentation caused by minocycline hydrochloride in wound therapy. Together with its ease of fabrication, high biocompatibility, high drug loading efficiency, and high release sustainability, CPS shows high potential to be developed into an intelligent solid‐state device for wound treatment in the future.

中文翻译：

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一种针对伤口治疗中双相化学感觉的内部信号的生物启发性，可持续释放材料

生命实体中的生物荧光是与信息传递相关的功能过程。而响应内部生理信号的能力是细胞的独特属性。通过将这两个生物学特征整合到材料设计中，开发了一种具有生物灵感的材料，即CPS。与常规发光聚合物系统相反，后者的发射来自π在共轭结构中，该材料显示了簇触发的发射。在组织修复的皮肤穿孔模型的临床前试验中，它成功地提高了伤口闭合的速度，减少了炎性细胞的浸润，并增强了胶原蛋白的沉积。它还可以将内部化学信号的变化转换成其固有发光的变化，以进行双相化学感应，以防止在伤口治疗中由盐酸米诺环素引起的皮肤色素沉着的发生。CPS具有易于制造，高生物相容性，高载药量和高释放可持续性的特点，显示出在将来发展为用于伤口治疗的智能固态设备的巨大潜力。