Background

Nongestational choriocarcinoma is a rare ovarian malignancy with a prognosis worse than that of gestational choriocarcinoma. Debulking surgery is the primary treatment for ovarian carcinoma. However, fertility preservation is important in young women.

Case

A 15-year-old girl with no sexual experience was admitted for abnormal uterine bleeding. Ultrasonography showed a solid mass in the right ovary and her serum β-human chorionic gonadotrophin levels were markedly elevated. We performed right oophorectomy, omentectomy, and peritoneal washing cytology. The uterus and left adnexa were preserved. She was diagnosed with nongestational choriocarcinoma, stage IIA. She received adjuvant chemotherapy (etoposide, methotrexate, actinomycin, cyclophosphamide, and oncovin regimen) and has been disease-free for more than 5 years.

Summary and Conclusion

Fertility-sparing surgery combined with chemotherapy is an acceptable treatment option for young patients with locally advanced nongestational choriocarcinoma.

中文翻译：

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成功治疗一名15岁女孩的非妊娠性绒毛膜癌：一例报告。

背景

非妊娠绒毛膜癌是一种罕见的卵巢恶性肿瘤，其预后比妊娠绒毛膜癌要差。散装手术是卵巢癌的主要治疗方法。但是，保持生育能力对年轻妇女很重要。

案件

一名无性经历的15岁女孩因子宫异常出血而入院。超声检查显示右卵巢有固体肿块，其血清β-人绒毛膜促性腺激素水平显着升高。我们进行了右卵巢切除术，网膜切除术和腹膜冲洗细胞学检查。保留子宫和左附件。她被诊断为IIA期非妊娠性绒毛膜癌。她接受了辅助化疗（依托泊苷，甲氨蝶呤，放线菌素，环磷酰胺和癌基因疗法），并且无病已超过5年。

总结与结论

对于年轻的局部晚期非妊娠性绒毛膜癌患者，保留生育力的手术与化学疗法相结合是一种可接受的治疗选择。