Purpose

To examine a possible case of Paget’s disease of bone (PDB) in an Indigenous pre-contact male from Canada, individual D of the Skinner site in Ontario.

Methods

Radiographs, CT scan and histological analysis.

Results

The histological analysis revealed the mosaic pattern that characterizes PDB. CT scans show advanced sclerosis of the cranium and a diminished diplӧe with osteolytic lesions.

Conclusions

The pathological features that have been identified are collectively characteristic of PDB.

Significance

The Skinner case advances our understanding of the global history and distribution of PDB.

Limitations of Study

Only two New World cases have been identified and neither has been studied in sufficient detail.

Suggestions for Future Research

The older individuals in precolonial New World skeletal series should be given CT scans, which are non-intrusive, to be followed by histological and genetic analyses when indicated.

中文翻译：

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加拿大安大略的斯金纳墓葬和美洲佩吉特病问题

目的

为了检查来自加拿大的原住民接触前男性佩吉特骨病 (PDB) 的可能病例，安大略省斯金纳 (Skinner) 站点的个体 D。

方法

X 光片、CT 扫描和组织学分析。

结果

组织学分析揭示了表征 PDB 的镶嵌模式。CT 扫描显示颅骨的晚期硬化和溶骨性病变的双侧减少。

结论

已确定的病理特征是 PDB 的共同特征。

意义

Skinner 案例加深了我们对 PDB 的全球历史和分布的理解。

学习的局限性

仅发现了两个新世界病例，并且都没有进行足够详细的研究。

对未来研究的建议

应该对前殖民新大陆骨骼系列中的老年人进行非侵入性 CT 扫描，然后在需要时进行组织学和遗传分析。