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A study of multinucleated giant cells in esophageal cancer
Clinical Immunology ( IF 8.6 ) Pub Date : 2020-11-13 , DOI: 10.1016/j.clim.2020.108600
Hui Wang , Junjie Zhou , Jun Li , Yiqun Geng , Pei Meng , Changchun Ma , Ziqi Zhu , Weifeng Zhang , Liangli Hong , Yan Quan , Jiacong Wei , Qiongyi Huang , You Zhou , Zuoqing Su , Xiaoqing Zhu , Chuangzhen Chen , Shaobin Chen , Jiang Gu

Objectives

To evaluate the occurrence, abundance, distribution, nature and clinical significance of multinucleated giant cell (MGC) in esophageal cancer.

Materials and methods

MGCs were examined with conventional pathology, immunohistochemistry and immunofluorescence in 107 esophageal cancer tissues. The findings were correlated to pathological diagnosis and clinical behavior of the cancers.

Results

MGCs were identified in 31.7% (34/107) of the cases. MGCs were positive for CD11c, CD11b, CD32, CD16, HLA-DR and MMP9, and negative for CD163, CD206 and CD64 giving a molecular profile of proinflammatory M1 but not immunosuppressive M2. MGCs were significantly related to decreased lymph node metastasis (p = 0.011), low pTNM stage (p = 0.044), favorable survival (p = 0.04), squamous cell cancer type rather than other histopathological subtypes (p = 0.020) and associated to better differentiation (p = 0.063).

Conclusions

MGCs belong to M1 macrophage and perform phagocytosis and scavenging of cancer cells that would benefit patients' survival and could serve as a prognostic marker.



中文翻译:

食管癌中多核巨细胞的研究

目标

评估食管癌中多核巨细胞(MGC)的发生,丰度,分布,性质和临床意义。

材料和方法

通过常规病理学,免疫组织化学和免疫荧光对107例食管癌组织中的MGC进行了检查。这些发现与癌症的病理诊断和临床行为相关。

结果

在31.7%(34/107)的病例中发现了MGC。MGC对CD11c,CD11b,CD32,CD16,HLA-DR和MMP9呈阳性,而对CD163,CD206和CD64呈阴性,从而给出了促炎性M1的分子谱,但没有免疫抑制性M2。MGC与淋巴结转移减少(p  = 0.011),pTNM分期低(p  = 0.044),良好的生存率(p = 0.04),鳞状细胞癌类型而不是其他组织病理学亚型(p  = 0.020)显着相关,且相关性更好差异(p  = 0.063)。

结论

MGC属于M1巨噬细胞,可以吞噬和清除癌细胞,这将有利于患者的生存并可以作为预后指标。

更新日期:2020-11-26
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