Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed an air stable and highly efficient CuFe₂O₄ heterogeneous catalyst for alkylation of indoles with alcohols to give bis(3-indolyl)methanes in very good yields. The CuFe₂O₄ catalyst has been found to be magnetically recycled at least five times without losing significant catalytic activity.

中文翻译：

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可磁循环使用的CuFe ₂ O ₄催化剂，可在温和条件下使用吲哚和醇高效合成双（吲哚基）甲烷

双（3-吲哚基）甲烷（BIM）具有很高的价值，并出现在许多天然产物和药理活性化合物（抗癌，抗炎，抗肥胖，抗肿瘤，抗微生物等）的核心结构中。在此，我们已经公开了一种空气稳定且高效的CuFe ₂ O ₄非均相催化剂，用于用醇将吲哚烷基化以非常好的收率得到双（3-吲哚基）甲烷。已经发现CuFe ₂ O ₄催化剂被磁循环至少五次而不会损失明显的催化活性。