The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders.

中文翻译：

---

瘦素下调 KCC2 活性并控制新生大鼠海马中的氯稳态

瘦素的典型生理作用是调节作用于特定下丘脑核的饥饿感和饱腹感。除了这个关键的代谢功能；瘦素还调节整个生命过程中神经元海马网络的发育和功能的许多方面。在这里，我们表明瘦素在体外控制发育中的大鼠海马中的氯离子稳态。瘦素的作用依赖于钾/氯化物挤出机 KCC2 活性的下调，并且存在于出生后发育的受限时期。这项研究证实并扩展了瘦素在功能性 GABA 能抑制个体发生中的作用，并有助于了解瘦素的异常水平如何导致神经系统疾病。