Biological rhythms regulate the biology of most, if not all living creatures, from whole organisms to their constitutive cells, their microbiota, and also parasites. Here, we present the hypothesis that internal and external ecological variations induced by biological cycles also influence or are exploited by cancer cells, especially by circulating tumor cells, the key players in the metastatic cascade. We then discuss the possible clinical implications of the effect of biological cycles on cancer progression, and how they could be exploited to improve and standardize methods used in the liquid biopsy field.

中文翻译：

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恶性细胞晚上睡觉吗？

生物节律调节大多数（如果不是全部）生物的生物学，从整个生物体到它们的组成细胞、微生物群以及寄生虫。在这里，我们提出了一个假设，即由生物循环引起的内部和外部生态变化也会影响或被癌细胞利用，特别是被循环肿瘤细胞（转移级联的关键参与者）所利用。然后，我们讨论生物周期对癌症进展的影响可能的临床意义，以及如何利用它们来改进和标准化液体活检领域中使用的方法。