Renal ischemia-reperfusion injury (RIRI) refers to a phenomenon associated with dysfunction of the kidney and tissue damage. Unfortunately, no specific drugs have been found that effectively prevent and treat RIRI. Curcumin (Cur), a polyphenol extracted from turmeric, possesses a variety of biological activities involving antioxidation, inhibition of apoptosis, inhibition of inflammation, and reduction of lipid peroxidation. Eight frequently used databases were searched using prespecified search strategies. The CAMARADES 10-item quality checklist was used to evaluate the risk of bias of included studies, and the RevMan 5.3 software was used to analyze the data. The risk of bias score of included studies ranged from 3 to 6 with an average score of 5.22. Compared with the control group, Cur significantly alleviated renal pathology, reduced blood urea nitrogen and serum creatinine levels, and improved inflammatory indexes, oxidant, and apoptosis in RIRI animal models. Despite the heterogeneity of the response to Cur in terms of serum creatinine, BUN, TNF-alpha, and SOD, its effectiveness for improving the injury of RIRI was remarkable. In the mouse model subgroup of serum creatinine, the effect size of the method of unilateral renal artery ligation with contralateral nephrectomy and shorter ischemic time showed a greater effect than that of the control group. No difference was seen in the methods of model establishment, mode administration, or medication times. The preclinical systematic review provided preliminary evidence that Cur partially improved RIRI in animal models, probably via anti-inflammatory, antioxidant, antiapoptosis, and antifibrosis activities and via improving microperfusion. ARRIVE guidelines are recommended; blinding and sample size calculation should be focused on in future studies. These data suggest that Cur is a potential renoprotective candidate for further clinical trials of RIRI.

中文翻译：

---

姜黄素保护肾脏缺血再灌注损伤的临床前系统评价

肾缺血再灌注损伤（RIRI）是指与肾功能障碍和组织损伤相关的现象。不幸的是，尚未发现有效预防和治疗RIRI的特定药物。姜黄素（Cur）是一种从姜黄中提取的多酚，具有多种生物活性，包括抗氧化，抑制细胞凋亡，抑制炎症和减少脂质过氧化。使用预先指定的搜索策略搜索了八个常用数据库。CAMARADES 10个项目的质量检查表用于评估纳入研究的偏倚风险，而RevMan 5.3软件用于分析数据。纳入研究的偏倚评分风险为3至6，平均评分为5.22。与对照组相比，Cur明显减轻了肾脏病理，降低了RIRI动物模型中的血液尿素氮和血清肌酐水平，并改善了炎症指标，氧化剂和细胞凋亡。尽管在血清肌酐，BUN，TNF-α和SOD方面对Cur的反应存在异质性，但它在改善RIRI损伤方面的有效性却很显着。在小鼠血清肌酐模型亚组中，单侧肾动脉结扎对侧肾切除术和较短的缺血时间的方法的效果大小显示出比对照组更大的效果。模型建立，模式管理或用药时间的方法无差异。临床前的系统评价提供了初步证据，表明Cur可能通过抗炎，抗氧化剂，抗凋亡，和抗纤维化活动以及通过改善微灌流。建议使用到达指导原则；致盲和样本量计算应在以后的研究中重点关注。这些数据表明，Cur是用于RIRI进一步临床试验的潜在的肾脏保护候选物。