In this study, an analytical method for the simultaneous determination of the novel insecticide flupyradifurone and its two metabolites in a variety of traditional Chinese herbal medicines was developed for the first time using high-performance liquid chromatography-tandem mass spectrometry. A simple and efficient method using dispersive solid-phase extraction was employed for the pretreatment of the samples. Several extractions and cleanup strategies were evaluated. The recoveries (n = 15) of flupyradifurone and its metabolites at three spiking levels were in the range 71.3%–101.7%, with corresponding intraday and interday relative standard deviations of 1.1%–14.8%. The limits of quantitation were 0.01 mg/kg for flupyradifurone and 0.1 mg/kg for its two metabolites. Overall, our developed method was sensitive and reliable for the fast screening of flupyradifurone and its two metabolites in traditional Chinese herbal medicine samples.

中文翻译：

---

改进的QuEChERS和高效液相色谱-串联质谱法测定中草药中的新型杀虫剂氟吡呋喃酮及其两种代谢物

在这项研究中，首次使用高效液相色谱-串联质谱法开发了一种同时测定多种中草药中新型杀虫剂氟吡呋喃酮及其两种代谢物的分析方法。使用分散固相萃取的简单有效方法对样品进行预处理。评估了几种提取和清除策略。回收率（n = 15）三种加标水平的氟吡呋喃及其代谢物的范围为71.3％–101.7％，相应的日内和日间相对标准偏差为1.1％–14.8％。氟吡呋喃的定量限为0.01 mg / kg，两种代谢物的定量限为0.1 mg / kg。总体而言，我们开发的方法灵敏可靠，可快速筛查中草药样品中的氟吡呋喃及其两种代谢产物。