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Adiponectin and Leptin Adipocytokines in Metabolic Syndrome: What Is Its Importance?
Dubai Diabetes and Endocrinology Journal Pub Date : 2020-09-17 , DOI: 10.1159/000510521
María Luz Gunturiz Albarracín , Ana Yibby Forero Torres

The global obesity epidemic has motivated a large number of investigations related to adipose tissue. Within the advances in this area, a variety of factors secreted by adipose tissue and with regulatory activity on caloric intake, energy expenditure, reproduction, locomotor activity, glycidic and lipid metabolism, immune response, and bone physiology have been described. Among these adipocyte hormones, collectively called “adipokines” or “adipocytokines,” leptin (LEP) and adiponectin are addressed in this review. The regulation of adipocytokines is altered in diseases such as obesity, atherosclerosis, type 2 diabetes mellitus, and metabolic syndrome (MS) due to the increase in the mass of white adipose tissue. LEP and adiponectin have a broad spectrum of functions in regulating metabolism and are an important link between obesity and MS. Because these adipocytokines have opposite effects on subclinical inflammation and insulin resistance, it has been suggested that the combined use of these 2 adipocytokines may work as a better biomarker in the diagnosis of MS than using them individually. In this review, we address the characteristics and main functions of adipocytokines derived from adipose tissue such as adiponectin and LEP, which in the Colombian context could give good guidance for the management of MS, especially in populations of children and adolescents.
Dubai Diabetes Endocrinol J


中文翻译:

代谢综合征中的脂联素和瘦素脂肪细胞因子:其重要性是什么?

全球肥胖病的流行已经激发了与脂肪组织有关的大量研究。在该领域的进展中,已经描述了脂肪组织分泌的各种因素,这些因素对热量的摄入,能量消耗,繁殖,运动能力,糖脂和脂质代谢,免疫反应以及骨骼生理具有调节活性。在这些脂肪细胞激素(统称为“脂肪细胞因子”或“脂肪细胞因子”)中,本研究涉及瘦素(LEP)和脂联素。由于白色脂肪组织质量的增加,肥胖,动脉粥样硬化,2型糖尿病和代谢综合征(MS)等疾病中脂肪细胞因子的调节发生改变。LEP和脂联素在调节新陈代谢方面具有广泛的功能,并且是肥胖与MS之间的重要纽带。由于这些脂肪细胞因子对亚临床炎症和胰岛素抵抗具有相反的作用,因此建议将这两种脂肪细胞因子联合使用可能比单独使用它们作为MS诊断的更好的生物标志物。在这篇综述中,我们探讨了来自脂肪组织(如脂联素和LEP)的脂肪细胞因子的特征和主要功能,这在哥伦比亚的背景下可以为MS的管理提供良好的指导,尤其是在儿童和青少年群体中。
迪拜糖尿病内分泌J
更新日期:2020-11-12
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