Objective: Serum uric acid (SUA) has been linked with development and progression of diabetic kidney disease (DKD). In this study, we intend to compare the effects of hyperuricemia (HUA) on beta-cell function, renal function, and lipid panels of patients with DKD. Methods: A total of 492 patients with DKD were included for data collection and analysis. Males and females have different standard SUA levels; thus, we analyzed these 2 groups separately. Normouricemia (NUA) for men (n = 253) was ≤428 μmol/L and for women (n = 83) was ≤357 μmol/L, whereas HUA for men (n = 94) was #x3e;428 μmol/L and for women (n = 62) was #x3e;357 μmol/L. Clinical characteristics of patients were analyzed based on gender-specific NUA and HUA. The Spearman rank correlation test was used to evaluate the correlation between SUA and other clinical variables. Finally, stepwise multinomial logistic regression test was performed to identify the factors that are independently associated with HUA. Results: A total of 492 patients were included in this study. The regression analysis showed that there was a significant association between HUA and decreased estimated glomerular filtration rate (eGFR) in both male and female patients (odds ratio (OR) [95% confidence interval (CI)] = 4.73 [2.19–10.24], p value ≤0.01 in male patients and OR [95% CI] = 3.07 [], p value = 0.04 in female patients). FBG, 2hPBG, and HbA1c were negatively correlated with SUA in male patients (r = −0.182, p value ≤0.01; r = −0.168, p value ≤0.01; and r = −0.187, p value ≤0.01, respectively), whereas fasting insulin was positively correlated in male patients (r = 0.131, p value = 0.023) and female patients (r = 0.192, p value = 0.041). The atherogenic index of plasma was significantly high in patients with HUA (OR [95% CI] = 5.75 [2.32–14.23], p value ≤0.01 in male patients and OR [95% CI] = 8.37 [1.96–35.78], p value ≤0.01 in female patients). Other indices of lipid profile such as lipoprotein combine index, atherosclerosis index, and triglyceride/high-density lipoprotein ratio were also independently associated with HUA in both male and female patients. Conclusion: SUA can affect various clinical parameters in patients with DKD. There is a significant association between HUA and decline in eGFR in both male and female patients. HUA is also associated with dyslipidemia in DKD, increasing the risk of cardiac complications and mortality.
Dubai Diabetes Endocrinol J

中文翻译：

---

高尿酸血症对糖尿病肾病患者β细胞功能，肾功能和血脂水平的影响：基于性别的回顾性研究

目的：血清尿酸（SUA）与糖尿病肾病（DKD）的发生和发展有关。在这项研究中，我们打算比较高尿酸血症（HUA）对DKD患者的β细胞功能，肾功能和血脂水平的影响。方法：共纳入492例DKD患者进行数据收集和分析。男性和女性的标准SUA水平有所不同；因此，我们分别分析了这两组。男性（ n = 253）的正常尿酸血症（NUA）≤428μmol/ L，女性（ n = 83）的≤357μmol/ L，而男性（ n = 94）的HUA为＃x3e; 428μmol/ L和女性（ ñ= 62）为＃x3e; 357μmol/ L。根据性别特定的NUA和HUA分析患者的临床特征。使用Spearman秩相关检验评估SUA与其他临床变量之间的相关性。最后，进行了逐步多项式逻辑回归测试，以确定与HUA独立相关的因素。结果：本研究共纳入492例患者。回归分析显示，男性和女性患者的HUA与估计的肾小球滤过率降低（eGFR）之间存在显着相关性（比值比（OR）[95％置信区间（CI）] = 4.73 [2.19-10.24]，男性患者的p值≤0.01，且OR [95％CI] = 3.07 []，p女性患者的平均价值= 0.04）。男性患者的FBG，2hPBG和HbA1c与SUA呈负相关（r = -0.182，p值≤0.01; r = -0.168，p值≤0.01; r = -0.187，p值≤0.01），而男性患者（r = 0.131，p值= 0.023）和女性患者（r = 0.192，p值= 0.041）的空腹胰岛素呈正相关。HUA患者血浆的动脉粥样硬化指数显着较高（OR [95％CI] = 5.75 [2.32-14.23]，男性患者的p值≤0.01，OR [95％CI] = 8.37 [1.96-35.78]，p女性患者的≤0.01）。在男性和女性患者中，血脂谱的其他指数，如脂蛋白结合指数，动脉粥样硬化指数和甘油三酯/高密度脂蛋白比率也与HUA独立相关。结论： SUA可以影响DKD患者的各种临床参数。在男性和女性患者中，HUA与eGFR下降之间存在显着关联。HUA还与DKD中的血脂异常有关，增加了心脏并发症和死亡的风险。
迪拜糖尿病内分泌J