Objective: The objective of this study was to assess the effects of continuous subcutaneous insulin infusion (CSII) therapy on glycaemic control and acute complications in children, adolescents, and young adults with type 1 diabetes mellitus (T1DM). Methods: The prospective observational study was done in patients on multiple daily injection (MDI) switching to pump system. All patients were followed at the Paediatric Diabetes Clinic at BIRDEM Hospital. They were trained on carbohydrates counting and started on continuous basal insulin infusion in addition to meal and high blood glucose correction insulin boluses. They were followed on insulin pump therapy for a 6-month period. Results: Twenty patients were analysed, from baseline to visit 2 after 6 months. The patients included in the study had T1DM for a mean duration of 4.7 ± 3.1 years. The age ranged from 3 to 25 years (mean 13.7 ± 6.1). There was 1% reduction in haemoglobin A1c (HbA1c) after 6 months, though it did not reach the statistical significance (p = 0.084). There was significant reduction of mean fasting blood glucose level 13.4 ± 7.0 versus 6.9 ± 1.6 mmol/L (p = 0.001), total insulin requirement (p = 0.043), frequency of hypoglycaemic episodes (p = 0.006), and diabetic ketoacidosis (p = 0.002) events during CSII therapy. Conclusion: In our study, we found that switching young T1DM patients from MDI to insulin pump had been effective with achievement of a reduction in fasting blood glucose, HbA1c, and acute complications.
Dubai Diabetes Endocrinol J

中文翻译：

---

连续皮下注射胰岛素对孟加拉国1型糖尿病年轻人血糖控制和急性并发症的影响

目的：本研究的目的是评估持续皮下注射胰岛素（CSII）治疗对1型糖尿病（T1DM）儿童，青少年和年轻人的血糖控制和急性并发症的影响。方法：前瞻性观察性研究是在患者多次每日注射（MDI）切换至泵系统的情况下进行的。所有患者均在BIRDEM医院的儿科糖尿病诊所接受了随访。他们除了接受进餐和高血糖校正胰岛素大剂量治疗外，还接受了碳水化合物计数方面的培训，并开始了连续基础胰岛素的输注。他们接受了6个月的胰岛素泵治疗。结果：从基线到6个月后访视2例，共分析了20例患者。纳入研究的患者患有T1DM，平均病程为4.7±3.1年。年龄范围为3至25岁（平均13.7±6.1）。6个月后血红蛋白A1c（HbA1c）减少了1％，尽管没有达到统计学显着性（p = 0.084）。平均空腹血糖水平明显降低，分别为13.4±7.0和6.9±1.6 mmol / L（p = 0.001），总胰岛素需求量（p = 0.043），低血糖发作频率（p = 0.006）和糖尿病性酮症酸中毒（p = 0.002）CSII治疗期间发生的事件。结论：在我们的研究中，我们发现，将年轻的T1DM患者从MDI切换到胰岛素泵已经有效，可以减少空腹血糖，HbA1c和急性并发症。
迪拜糖尿病内分泌J