当前位置:
X-MOL 学术
›
J. Asian Nat. Prod. Res.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis and antiviral activity of lycorine derivatives
Journal of Asian Natural Products Research ( IF 1.7 ) Pub Date : 2020-11-12 , DOI: 10.1080/10286020.2020.1844674 Ya-Jun Yang 1 , Jiang-Ning Liu 2 , Xian-Dao Pan 1
中文翻译:
赖氨酸衍生物的合成及其抗病毒活性
更新日期:2020-11-25
Journal of Asian Natural Products Research ( IF 1.7 ) Pub Date : 2020-11-12 , DOI: 10.1080/10286020.2020.1844674 Ya-Jun Yang 1 , Jiang-Ning Liu 2 , Xian-Dao Pan 1
Affiliation
Abstract
There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine. In addition, derivative 7e enhanced the survival rate to 40% in the mouse model of the lethal EV71 infection.
中文翻译:
赖氨酸衍生物的合成及其抗病毒活性
摘要
没有有效的抗病毒药物来治疗手足口病。在这项研究中,合成了一系列的lycorine衍生物,并在体外针对肠病毒71和柯萨奇病毒A16进行了评估。在C-1位置带有苯氧酰基的衍生物7c-m比番茄红素具有更高的功效和更低的毒性。此外,在致命的EV71感染的小鼠模型中,衍生物7e将存活率提高到40%。